Ontology highlight
ABSTRACT:
SUBMITTER: McCullough LE
PROVIDER: S-EPMC4369423 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
McCullough Lauren E LE Eng Sybil M SM Bradshaw Patrick T PT Cleveland Rebecca J RJ Steck Susan E SE Terry Mary Beth MB Shen Jing J Crew Katherine D KD Rossner Pavel P Ahn Jiyoung J Ambrosone Christine B CB Teitelbaum Susan L SL Neugut Alfred I AI Santella Regina M RM Gammon Marilie D MD
Annals of epidemiology 20150124 4
<h4>Purpose</h4>Obesity is associated with increased bioavailability of estrogen, hyperinsulinemia, and chronic inflammation, all of which may promote tumor growth. Given DNA repair and oxidative stress pathways may work together with these mechanisms to influence carcinogenesis, we hypothesized that genetic variation in these pathways may modify the obesity-postmenopausal breast cancer (BC) association.<h4>Methods</h4>Resources from a population-based case-control study (990 cases and 970 contr ...[more]