The transcriptional response to tumorigenic polarity loss in Drosophila.
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ABSTRACT:
SUBMITTER: Bunker BD
PROVIDER: S-EPMC4369581 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
The transcriptional response to tumorigenic polarity loss in Drosophila.
Bunker Brandon D BD Nellimoottil Tittu T TT Boileau Ryan M RM Classen Anne K AK Bilder David D
eLife 20150226
Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic investigation. RNA profiling of Scrib mutant tumors reveals multiple signatures of neoplasia, including altered metabolism and dedifferentiation. Prominent among these is upregulation of cytokine-like Unp ...[more]
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