Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
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ABSTRACT:
SUBMITTER: Herrmann L
PROVIDER: S-EPMC4370497 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
Herrmann Lydia L Wiegmann Caspar C Arsalan-Werner Annika A Hilbrich Isabel I Jäger Carsten C Flach Katharina K Suttkus Anne A Lachmann Ingolf I Arendt Thomas T Holzer Max M
PloS one 20150323 3
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes. Furthermore, Hook proteins are associated with pathological hallmarks in AD; Hook1 and Hook3 are localized to tau aggregates and Hook2 to glial components within amyloid plaques. A ...[more]
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