SNP marker discovery in koala TLR genes.
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ABSTRACT:
SUBMITTER: Cui J
PROVIDER: S-EPMC4370664 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
SNP marker discovery in koala TLR genes.
Cui Jian J Frankham Greta J GJ Johnson Rebecca N RN Polkinghorne Adam A Polkinghorne Adam A Timms Peter P O'Meally Denis D Cheng Yuanyuan Y Belov Katherine K
PloS one 20150323 3
Toll-like receptors (TLRs) play a crucial role in the early defence against invading pathogens, yet our understanding of TLRs in marsupial immunity is limited. Here, we describe the characterisation of nine TLRs from a koala immune tissue transcriptome and one TLR from a draft sequence of the koala genome and the subsequent development of an assay to study genetic diversity in these genes. We surveyed genetic diversity in 20 koalas from New South Wales, Australia and showed that one gene, TLR10 ...[more]
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