Ontology highlight
ABSTRACT:
SUBMITTER: Das P
PROVIDER: S-EPMC4371604 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Das Prasanta P Omollo Ann O AO Sitole Lungile J LJ McClendon Eric E Valente Edward J EJ Raucher Drazen D Walker Leslie R LR Hamme Ashton T AT
Tetrahedron letters 20150401 14
A series of structurally diverse 4-bromo spiro-isoxazolines possessing a variety of aromatic and aliphatic substituents at the 3 position, were synthesized through a 1,3-dipolar cycloaddition followed by intramolecular cyclization of a pendant hydroxyl or carboxylic acid group. The biochemical antiproliferative activity was evaluated <i>in vitro</i> by using two breast cancer cell lines (MCF-7 and MDA-MB-231) and two prostate cancer cell lines (PC-3 and DU-145) using the MTT viability assay, and ...[more]