Ontology highlight
ABSTRACT:
SUBMITTER: Stokes JM
PROVIDER: S-EPMC4371806 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Stokes Jonathan M JM Davis Joseph H JH Mangat Chand S CS Williamson James R JR Brown Eric D ED
eLife 20140918
While small molecule inhibitors of the bacterial ribosome have been instrumental in understanding protein translation, no such probes exist to study ribosome biogenesis. We screened a diverse chemical collection that included previously approved drugs for compounds that induced cold sensitive growth inhibition in the model bacterium Escherichia coli. Among the most cold sensitive was lamotrigine, an anticonvulsant drug. Lamotrigine treatment resulted in the rapid accumulation of immature 30S and ...[more]