Ontology highlight
ABSTRACT:
SUBMITTER: Pylypenko O
PROVIDER: S-EPMC4371908 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Pylypenko Olena O Song Lin L Shima Ai A Yang Zhaohui Z Houdusse Anne M AM Sweeney H Lee HL
Proceedings of the National Academy of Sciences of the United States of America 20150306 11
Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and destroyed the ability of single dimeric molecules to move processively on actin filaments. We observed that processive movement is rescued if ATP is added to the mutant dimer following binding of both h ...[more]