Ontology highlight
ABSTRACT:
SUBMITTER: Osterndorff-Kahanek EA
PROVIDER: S-EPMC4372440 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Osterndorff-Kahanek Elizabeth A EA Becker Howard C HC Lopez Marcelo F MF Farris Sean P SP Tiwari Gayatri R GR Nunez Yury O YO Harris R Adron RA Mayfield R Dayne RD
PloS one 20150324 3
Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and represents an animal model of physical dependence. We examined time- and brain region-dependent changes in gene coexpression networks in amygdala (AMY), nucleus accumbens (NAC), prefrontal cortex (PFC), and liver after four weekly cycles of chronic intermittent ethanol (CIE) vapor exposure in C57BL/6J mice. Microarrays were used to compare gene expression profiles at 0-, 8-, and 120-hours following the last ethanol ...[more]