Ontology highlight
ABSTRACT:
SUBMITTER: Farlow JL
PROVIDER: S-EPMC4372548 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Farlow Janice L JL Lin Hai H Sauerbeck Laura L Lai Dongbing D Koller Daniel L DL Pugh Elizabeth E Hetrick Kurt K Ling Hua H Kleinloog Rachel R van der Vlies Pieter P Deelen Patrick P Swertz Morris A MA Verweij Bon H BH Regli Luca L Rinkel Gabriel J E GJ Ruigrok Ynte M YM Doheny Kimberly K Liu Yunlong Y Broderick Joseph J Foroud Tatiana T
PloS one 20150324 3
Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has not been fully explored. In this study, we report the use of whole exome sequencing (WES) in seven densely-affected families (45 individuals) recruited as part of the Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, p ...[more]