Functional characterization of a BCL10 isoform in the rainbow trout Oncorhynchus mykiss.
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ABSTRACT:
SUBMITTER: Mazzone P
PROVIDER: S-EPMC4372615 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Functional characterization of a BCL10 isoform in the rainbow trout Oncorhynchus mykiss.
Mazzone Pellegrino P Scudiero Ivan I Coccia Elena E Ferravante Angela A Paolucci Marina M D'Andrea Egildo Luca EL Varricchio Ettore E Pizzulo Maddalena M Reale Carla C Zotti Tiziana T Vito Pasquale P Stilo Romania R
FEBS open bio 20150204
The complexes formed by BCL10, MALT1 and members of the family of CARMA proteins have recently been the focus of much attention because they represent a key mechanism for regulating activation of the transcription factor NF-κB. Here, we report the functional characterization of a novel isoform of BCL10 in the trout Oncorhynchus mykiss, which we named tBCL10. tBCL10 dimerizes, binds to components of the CBM complex and forms cytoplasmic filaments. Functionally, tBCL10 activates NF-κB transcriptio ...[more]
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