A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
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ABSTRACT:
SUBMITTER: Morgan RE
PROVIDER: S-EPMC4372856 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
Morgan Rachel E RE Chudasama Vijay V Moody Paul P Smith Mark E B ME Caddick Stephen S
Organic & biomolecular chemistry 20150304 14
Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones. ...[more]
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