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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

ABSTRACT: Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.

SUBMITTER: Morgan RE 

PROVIDER: S-EPMC4372856 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

Morgan Rachel E RE   Chudasama Vijay V   Moody Paul P   Smith Mark E B ME   Caddick Stephen S  

Organic & biomolecular chemistry 20150304 14

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones. ...[more]

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