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Growth factors in ischemic stroke.

ABSTRACT: Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1? and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.

SUBMITTER: Lanfranconi S

PROVIDER: S-EPMC4373358 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Growth factors in ischemic stroke.

Lanfranconi S S Locatelli F F Corti S S Candelise L L Comi G P GP Baron P L PL Strazzer S S Bresolin N N Bersano A A

Journal of cellular and molecular medicine 20091208 8

Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyt ...[more]

PMID: 20015202

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Linking Notch signaling to ischemic stroke

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Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months.

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