Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4373539 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Chen Yiming Y Lin Yen-Chu YC Kuo Tzu-Wei TW Knight Zachary A ZA
Cell 20150219 5
Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recording of the natural activity of two key cell types that control food intake, AgRP and POMC neurons, in awake behaving mice. We find unexpectedly that the sensory detection of food is sufficient to rapidly ...[more]