Ontology highlight
ABSTRACT:
SUBMITTER: Arnatt CK
PROVIDER: S-EPMC4373595 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Arnatt Christopher Kent CK Zhang Yan Y
Current topics in medicinal chemistry 20140101 13
Increasing evidence has shown that chemokine receptors may form functional dimers with unique pharmacological profiles. A common practice to characterize such G protein-coupled receptor dimerization processes is to apply bivalent ligands as chemical probes which can interact with both receptors simultaneously. Currently, two chemokine receptor dimers have been studied by applying bivalent compounds: the CXCR4-CXCR4 homodimer and the CCR5-MOR heterodimer. These bivalent compounds have revealed ho ...[more]