Ontology highlight
ABSTRACT:
SUBMITTER: Zhu YP
PROVIDER: S-EPMC4374698 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhu Yan-Ping YP Peng Zong-Gen ZG Wu Zhou-Yi ZY Li Jian-Rui JR Huang Meng-Hao MH Si Shu-Yi SY Jiang Jian-Dong JD
PloS one 20150326 3
Human APOBEC3G (hA3G) is a cytidine deaminase that restricts replication of certain viruses. We have previously reported that hA3G was a host restriction factor against hepatitis C virus (HCV) replication, and hA3G stabilizers showed a significant inhibitory activity against HCV. However, the molecular mechanism of hA3G against HCV remains unknown. We show in this study that hA3G's C-terminal directly binds HCV non-structural protein NS3 at its C-terminus, which is responsible for NS3's helicase ...[more]