Influence of phthalates on cytokine production in monocytes and macrophages: a systematic review of experimental trials.

ABSTRACT:

Background

Phthalates are a group of endocrine disrupting chemicals suspected to influence the immune system. The aim of this systematic review is to summarise the present knowledge on the influence of phthalates on monocyte and macrophage production and secretion of cytokines, an influence which could affect both pro- and anti-inflammatory abilities of these cells.

Strategy and results

A systematic search was performed in Medline, Embase and Toxline in June 2013, last updated 3rd of August 2014. Criteria used to select studies were described and published beforehand online on Prospero (http://www.crd.york.ac.uk/NIHR_PROSPERO, registration number CRD42013004236). In vivo, ex vivo and in vitro studies investigating the influence of phthalates on cytokine mRNA expression and c

SUBMITTER: Hansen JF 

PROVIDER: S-EPMC4374770 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature