YAP enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation.
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ABSTRACT:
SUBMITTER: Song Q
PROVIDER: S-EPMC4374846 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
YAP enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation.
Song Qinghe Q Mao Beibei B Cheng Jinbo J Gao Yuhao Y Jiang Ke K Chen Jun J Yuan Zengqiang Z Meng Songshu S
PloS one 20150326 3
The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor suppressor pathway, functions as an oncoprotein in a variety of cancers. However, its contribution to breast cancer remains controversial. This study investigated the role of YAP in breast cancer cells under nutrient deprivation (ND). Here, we show that YAP knockdown sensitized MCF7 breast cancer cells to nutrient deprivation-induced apoptosis. Furthermore, in response to ND, YAP increased the autolyso ...[more]
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