Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe R
PROVIDER: S-EPMC4375457 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Watanabe Rikiya R Koyasu Kazuma K You Huijuan H Tanigawara Mizue M Noji Hiroyuki H
Biophysical journal 20150301 5
F1-ATPase (F1) is an ATP-driven rotary motor in which the three catalytic β subunits in the stator ring sequentially induce the unidirectional rotation of the rotary γ subunit. Many lines of evidence have revealed open-to-closed conformational transitions in the β subunit that swing the C-terminal domain inward. This conformational transition causes a C-terminal protruding loop with conserved sequence DELSEED to push the γ subunit. Previous work, where all residues of DELSEED were substituted wi ...[more]