Ontology highlight
ABSTRACT:
SUBMITTER: Lin W
PROVIDER: S-EPMC4375500 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20150112 13
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). Our previous report indicates that IBDV VP5 induces apoptosis via interaction with voltage-dependent anion channel 2 (VDAC2). However, the underlying molecular mechanism is still unclear. We report here that receptor of activated protein kinase C 1 (RACK1) interacts with both VDAC2 and VP5 and that they could form a complex. We found that overexpression of RACK1 inhibit ...[more]