Lipoprotein particles and size, total and high molecular weight adiponectin, and leptin in relation to incident coronary heart disease among severely obese postmenopausal women: The Women's Health Initiative Observational Study.

ABSTRACT:

Background

We hypothesized that higher concentrations of LDL particles (LDL-P) and leptin, and lower concentrations of HDL particles (HDL-P), and total and high molecular weight (HMW) adiponectin, would predict incident coronary heart disease (CHD) among severely obese postmenopausal women.

Methods

In a case-cohort study nested in the Women's Health Initiative Observational Study, we sampled 677 of the 1852 white or black women with body mass index (BMI) ≥40 kg/m² and no prevalent cardiovascular disease (CVD), including all 124 cases of incident CHD over mean 5.0 year follow-up. Biomarkers were assayed on stored blood samples.

Results

In multivariable-adjusted weighted Cox models, higher baseline levels of total and small LDL-P, and lower levels of total an

SUBMITTER: Mackey RH 

PROVIDER: S-EPMC4375554 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature