Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations.
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ABSTRACT:
SUBMITTER: Kim BY
PROVIDER: S-EPMC4375557 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations.
Kim Bernard Y BY Lohmueller Kirk E KE
American journal of human genetics 20150212 3
It has been hypothesized that the greater proportion of Neandertal ancestry in East Asians than in Europeans is due to the fact that purifying selection is less effective at removing weakly deleterious Neandertal alleles from East Asian populations. Using simulations of a broad range of models of selection and demography, we have shown that this hypothesis cannot account for the higher proportion of Neandertal ancestry in East Asians than in Europeans. Instead, more complex demographic scenarios ...[more]
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