Ontology highlight
ABSTRACT:
SUBMITTER: Oertel-Knochel V
PROVIDER: S-EPMC4375641 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Oertel-Knöchel Viola V Lancaster Thomas M TM Knöchel Christian C Stäblein Michael M Storchak Helena H Reinke Britta B Jurcoane Alina A Kniep Jonathan J Prvulovic David D Mantripragada Kiran K Tansey Katherine E KE O'Donovan Michael C MC Owen Michael J MJ Linden David E J DE
NeuroImage. Clinical 20150313
Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimaging has developed into a powerful tool of translational neuroscience. In this study, we used genome wide significant SZ risk variants to test the predictive capacity of the polygenic model and explore ...[more]