Ontology highlight
ABSTRACT:
SUBMITTER: Du ZW
PROVIDER: S-EPMC4375778 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Du Zhong-Wei ZW Chen Hong H Liu Huisheng H Lu Jianfeng J Qian Kun K Huang CindyTzu-Ling CL Zhong Xiaofen X Fan Frank F Zhang Su-Chun SC
Nature communications 20150325
Human pluripotent stem cells (hPSCs) have opened new opportunities for understanding human development, modelling disease processes and developing new therapeutics. However, these applications are hindered by the low efficiency and heterogeneity of cell types, such as motorneurons (MNs), differentiated from hPSCs as well as our inability to maintain the potency of lineage-committed progenitors. Here by using a combination of small molecules that regulate multiple signalling pathways, we develop ...[more]