Ontology highlight
ABSTRACT:
SUBMITTER: Jin H
PROVIDER: S-EPMC4376475 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Jin Hongting H Wang Baoli B Li Jia J Xie Wanqing W Mao Qiang Q Li Shan S Dong Fuqiang F Sun Yan Y Ke Hua-Zhu HZ Babij Philip P Tong Peijian P Chen Di D
Bone 20140928
In this study we investigated if Wnt/β-catenin signaling in mesenchymal progenitor cells plays a role in bone fracture repair and if DKK1-Ab promotes fracture healing through activation of β-catenin signaling. Unilateral open transverse tibial fractures were created in CD1 mice and in β-catenin(Prx1ER) conditional knockout (KO) and Cre-negative control mice (C57BL/6 background). Bone fracture callus tissues were collected and analyzed by radiography, micro-CT (μCT), histology, biomechanical test ...[more]