Ontology highlight
ABSTRACT:
SUBMITTER: Kakugawa S
PROVIDER: S-EPMC4376489 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kakugawa Satoshi S Langton Paul F PF Zebisch Matthias M Howell Steve S Chang Tao-Hsin TH Liu Yan Y Feizi Ten T Bineva Ganka G O'Reilly Nicola N Snijders Ambrosius P AP Jones E Yvonne EY Vincent Jean-Paul JP
Nature 20150225 7542
Signalling by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback antagonist. Notum has been thought to act as a phospholipase, shedding glypicans and associated Wnt proteins from the cell surface. However, this view fails to explain specificity, as glypicans bind many extracellular ligands. Here we provide genetic evidence in Drosophila that Notum requi ...[more]