Ontology highlight
ABSTRACT:
SUBMITTER: Chen YH
PROVIDER: S-EPMC4376586 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Chen Yi-Hsien YH McGowan Lucy D'Agostino LD Cimino Patrick J PJ Dahiya Sonika S Leonard Jeffrey R JR Lee Da Yong DY Gutmann David H DH
Cell reports 20150312 11
The availability of adult malignant glioma stem cells (GSCs) has provided unprecedented opportunities to identify the mechanisms underlying treatment resistance. Unfortunately, there is a lack of comparable reagents for the study of pediatric low-grade glioma (LGG). Leveraging a neurofibromatosis 1 (Nf1) genetically engineered mouse LGG model, we report the isolation of CD133(+) multi-potent low-grade glioma stem cells (LG-GSCs), which generate glioma-like lesions histologically similar to the p ...[more]