Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC4377070 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zhang Peijing P Wang Li L Rodriguez-Aguayo Cristian C Yuan Yuan Y Debeb Bisrat G BG Chen Dahu D Sun Yutong Y You M James MJ Liu Yongqing Y Dean Douglas C DC Woodward Wendy A WA Liang Han H Yang Xianbin X Lopez-Berestein Gabriel G Sood Anil K AK Hu Ye Y Ang K Kian KK Chen Junjie J Ma Li L
Nature communications 20141205
Tumour cells associated with therapy resistance (radioresistance and drug resistance) are likely to give rise to local recurrence and distant metastatic relapse. Recent studies revealed microRNA (miRNA)-mediated regulation of metastasis and epithelial-mesenchymal transition; however, whether specific miRNAs regulate tumour radioresistance and can be exploited as radiosensitizing agents remains unclear. Here we find that miR-205 promotes radiosensitivity and is downregulated in radioresistant sub ...[more]