Ontology highlight
ABSTRACT:
SUBMITTER: Xu HG
PROVIDER: S-EPMC4377312 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Xu H-G HG Zhai Y-X YX Chen J J Lu Y Y Wang J-W JW Quan C-S CS Zhao R-X RX Xiao X X He Q Q Werle K D KD Kim H-G HG Lopez R R Cui R R Liang J J Li Y-L YL Xu Z-X ZX
Oncogene 20140929 29
Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutated in Peutz-Jeghers syndrome and in a variety of sporadic cancers. Herein, we demonstrate that LKB1 controls the levels of intracellular reactive oxygen species (ROS) and protects the genome from oxidative damage. Cells lacking LKB1 exhibit markedly increased intracellular ROS levels, excessive oxidation of DNA, increased mutation rates and accumulation of DNA damage, which are effectively prevente ...[more]