A new class of cancer-associated PTEN mutations defined by membrane translocation defects.
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ABSTRACT:
SUBMITTER: Nguyen HN
PROVIDER: S-EPMC4377315 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
A new class of cancer-associated PTEN mutations defined by membrane translocation defects.
Nguyen H-N HN Yang J-M JM Rahdar M M Keniry M M Swaney K F KF Parsons R R Park B H BH Sesaki H H Devreotes P N PN Iijima M M
Oncogene 20140929 28
Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signaling, is a commonly mutated tumor suppressor. The majority of cancer-associated PTEN mutations block its essential PIP3 phosphatase activity. However, there is a group of clinically identified PTEN mutations that maintain enzymatic activity, and it is unknown how these mutations contribute to tumor pathogenesis. Here, we show that these enzymatically competent PTEN ...[more]
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