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TNF, IL12B, and IFNG Gene Polymorphisms in Serbian Patients with Psoriasis.


ABSTRACT: BACKGROUND:Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-?), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-?) are released from various inflammatory and resident cells, and have been implicated in the initiation/maintenance of inflammation. Certain alleles of the aforementioned cytokines may be associated with disease susceptibility/severity. OBJECTIVE:To investigate the association of three common functional gene polymorphisms, namely TNF -308 G/A (rs1800629), IL12B (encoding the p40 subunit of IL-12/23) +1188 A/C (rs3212227), and IFNG +874 T/A (rs2430561) with psoriasis development and severity in Serbian patients. METHODS:We genotyped 130 patients with psoriasis (26 of whom also had psoriatic arthritis) and 259 controls; rs1800629 and rs3212227, and rs2430561, by real-time PCR assay. RESULTS:The TNF GG genotype was detected at a higher frequency in patients with psoriasis compared to control subjects (OR, 1.420; 95% CI, 0.870~2.403) without statistical significance (p=0.191). Lack of the TNF G allele was associated with lower psoriasis severity (p=0.007). The IL12B AC genotype was underrepresented in the patients with psoriatic arthritis compared to healthy subjects (OR, 0.308; 95% CI, 0.090~1.057; p=0.049). The distribution of the rs2430561 allele and genotype frequencies was similar between patients with psoriasis and controls. CONCLUSION:Our study demonstrates an effect of the rs1800629 on psoriasis severity, and a marginal impact of the rs3212227 on susceptibility to psoriatic arthritis. Collectively, our results obtained in a Serbian cohort expand current knowledge regarding individual predisposition to psoriatic disease.

SUBMITTER: Popadic S 

PROVIDER: S-EPMC4377400 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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TNF, IL12B, and IFNG Gene Polymorphisms in Serbian Patients with Psoriasis.

Popadic Svetlana S   Savic Emina E   Markovic Milos M   Ramic Zorica Z   Medenica Ljiljana L   Pravica Vera V   Spuran Zorica Z   Trajkovic Vladimir V   Popadic Dusan D  

Annals of dermatology 20150324 2


<h4>Background</h4>Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the initiation/maintenance of inflammation. Certain alleles of the aforementioned cytokines may be associated with disease susceptibility/severity.<h4>Objective</h4>To investigate  ...[more]

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