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Crystalloid glomerulopathy in monoclonal gammopathy of renal significance (MGRS).

ABSTRACT: We report a case of monoclonal gammopathy of renal significance in a 63-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. The kidney biopsy showed a membranoproliferative glomerulonephritis pattern with extensive crystalloid deposits in the glomerular capillary endothelial cells and very few in the tubular epithelial cells. The immunoperoxidase staining showed kappa light chain restriction. Subsequently, the bone marrow showed 6% plasma cells which confirmed the diagnosis of monoclonal gammopathy of renal significance. He responded well to bortezomib treatment with resolution of the nephrotic syndrome and normalization of renal function after 7 months.

SUBMITTER: Vankalakunti M

PROVIDER: S-EPMC4377747 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Crystalloid glomerulopathy in monoclonal gammopathy of renal significance (MGRS).

Vankalakunti Mahesha M Bonu Ravishankar R Shetty Shilpa S Siddini Vishwanath V Babu Kishore K Ballal Sudarshan H SH

Clinical kidney journal 20140318 3

We report a case of monoclonal gammopathy of renal significance in a 63-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. The kidney biopsy showed a membranoproliferative glomerulonephritis pattern with extensive crystalloid deposits in the glomerular capillary endothelial cells and very few in the tubular epithelial cells. The immunoperoxidase staining showed kappa light chain restriction. Subsequently, the bone marrow showed 6% plasma cells which confirmed th ...[more]

PMID: 25852893

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Rate and Predictors of Finding Monoclonal Gammopathy of Renal Significance (MGRS) Lesions on Kidney Biopsy in Patients with Monoclonal Gammopathy.

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