Ontology highlight
ABSTRACT:
SUBMITTER: Kapoor P
PROVIDER: S-EPMC4378192 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kapoor Prabodh P Bao Yunhe Y Xiao Jing J Luo Jie J Shen Jianfeng J Persinger Jim J Peng Guang G Ranish Jeff J Bartholomew Blaine B Shen Xuetong X
Genes & development 20150301 6
ATP-dependent chromatin remodeling complexes alter chromatin structure through interactions with chromatin substrates such as DNA, histones, and nucleosomes. However, whether chromatin remodeling complexes have the ability to regulate nonchromatin substrates remains unclear. Saccharomyces cerevisiae checkpoint kinase Mec1 (ATR in mammals) is an essential master regulator of genomic integrity. Here we found that the SWI/SNF chromatin remodeling complex is capable of regulating Mec1 kinase activit ...[more]