Ontology highlight
ABSTRACT:
SUBMITTER: Vourekas A
PROVIDER: S-EPMC4378194 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Vourekas Anastassios A Zheng Ke K Fu Qi Q Maragkakis Manolis M Alexiou Panagiotis P Ma Jing J Pillai Ramesh S RS Mourelatos Zissimos Z Wang P Jeremy PJ
Genes & development 20150311 6
Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions of most of the factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show that MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and that a point mutation that abolishes this activity causes a failure in primary piRNA biogenesis in vivo. We ...[more]