Ontology highlight
ABSTRACT:
SUBMITTER: Sim C
PROVIDER: S-EPMC4378412 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Sim Cheolho C Kang David S DS Kim Sungshil S Bai Xiaodong X Denlinger David L DL
Proceedings of the National Academy of Sciences of the United States of America 20150309 12
Insulin and juvenile hormone signaling direct entry of the mosquito Culex pipiens into its overwintering adult diapause, and these two critical signaling pathways appear to do so by converging on the regulation of forkhead transcription factor (FOXO). Diapause is a complex phenotype, and FOXO emerges as a prime candidate for activating many of the diverse physiological pathways that generate the diapause phenotype. Here, we used ChIP sequencing to identify direct targets of FOXO. The nearest gen ...[more]