Unknown

Dataset Information

0

Population structure and antimicrobial resistance of invasive serotype IV group B Streptococcus, Toronto, Ontario, Canada.


ABSTRACT: We recently showed that 37/600 (6.2%) invasive infections with group B Streptococcus (GBS) in Toronto, Ontario, Canada, were caused by serotype IV strains. We report a relatively high level of genetic diversity in 37 invasive strains of this emerging GBS serotype. Multilocus sequence typing identified 6 sequence types (STs) that belonged to 3 clonal complexes. Most isolates were ST-459 (19/37, 51%) and ST-452 (11/37, 30%), but we also identified ST-291, ST-3, ST-196, and a novel ST-682. We detected further diversity by performing whole-genome single-nucleotide polymorphism analysis and found evidence of recombination events contributing to variation in some serotype IV GBS strains. We also evaluated antimicrobial drug resistance and found that ST-459 strains were resistant to clindamycin and erythromycin, whereas strains of other STs were, for the most part, susceptible to these antimicrobial drugs.

SUBMITTER: Teatero S 

PROVIDER: S-EPMC4378482 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6154151 | biostudies-literature
| S-EPMC3993709 | biostudies-literature
| S-EPMC90860 | biostudies-literature
| S-EPMC5088005 | biostudies-literature
| S-EPMC4540936 | biostudies-literature
| S-EPMC6844036 | biostudies-literature
| S-EPMC4702752 | biostudies-literature
| S-EPMC6910703 | biostudies-literature
| S-EPMC5277510 | biostudies-literature
| S-EPMC3858295 | biostudies-literature