Ontology highlight
ABSTRACT:
SUBMITTER: Jacoby MA
PROVIDER: S-EPMC4378713 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Jacoby Meagan A MA Martin Michael G MG Uy Geoffrey L GL Westervelt Peter P Dipersio John F JF Cashen Amanda A Stockerl-Goldstein Keith K Vij Ravi R Luo Jingqin J Reineck Teresa T Bernabe Noel N Abboud Camille N CN
American journal of hematology 20140303 5
Clofarabine has shown activity and tolerability in older patients with acute myeloid leukemia (AML). We investigated the safety and tolerability of an oral formulation of clofarabine for consolidation therapy of patients aged 60 and older with AML. In this phase I study, twenty-two patients older than 60 years with AML in first complete remission were treated once daily with oral clofarabine for 14 or 21 days of a 28-day cycle, for up to five cycles. Dose escalation from 1 mg to 6 mg daily using ...[more]