Ontology highlight
ABSTRACT:
SUBMITTER: Guzman ML
PROVIDER: S-EPMC4378904 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Stem cells (Dayton, Ohio) 20140401 4
Despite increased comprehension of acute myelogenous leukemia (AML) pathogenesis, current treatment strategies have done little to improve upon standard induction chemotherapy to induce long-term remissions. Since the identification of the leukemic stem cell, efforts have been placed on identifying therapeutically actionable pathways that distinguish this increasingly important cellular compartment. With the advent of increased genome sequencing efforts and phenotypic characterization, opportuni ...[more]