Transcriptomics of maternal and fetal membranes can discriminate between gestational-age matched preterm neonates with and without cognitive impairment diagnosed at 18-24 months.

ABSTRACT:

Background

Neurocognitive impairment among children born preterm may arise from complex interactions between genes and the intra-uterine environment.

Objectives

(1) To characterize the transcriptomic profiles of chorioamniotic membranes in preterm neonates with and without neurocognitive impairment via microarrays and (2) to determine if neonates with neurocognitive impairment can be identified at birth.

Materials/methods

A retrospective case-control study was conducted to examine the chorioamniotic transcriptome of gestational-age matched very preterm neonates with and without neurocognitive impairment at 18-24 months' corrected-age defined by a Bayley-III Cognitive Composite Score <80 (n = 14 each). Pathway analysis with down-weighting of overlapping genes (PADOG) w

SUBMITTER: Pappas A 

PROVIDER: S-EPMC4379164 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature