Ontology highlight
ABSTRACT:
SUBMITTER: Nash GM
PROVIDER: S-EPMC4380015 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Nash Garrett M GM Gimbel Mark M Cohen Alfred M AM Zeng Zhao-Shi ZS Ndubuisi Mackevin I MI Nathanson Daniel R DR Ott Jurg J Barany Francis F Paty Philip B PB
Annals of surgical oncology 20091008 2
<h4>Introduction</h4>We examined two genetic markers established early in colorectal tumor development, microsatellite instability (MSI) and mutation of the KRAS proto-oncogene, to see if these genetic changes influence metastatic disease progression and survival.<h4>Patients and methods</h4>MSI and KRAS mutation status were assessed in 532 primary adenocarcinomas (stage I-IV) from patients treated by colon resection. Median follow-up was 4.1 years (range 0-13.3 years) overall, 5.4 years for sur ...[more]