Ontology highlight
ABSTRACT:
SUBMITTER: Dang H
PROVIDER: S-EPMC4380258 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
BMC cancer 20150321
<h4>Background</h4>Hepatocellular carcinoma (HCC) patients with active hepatocyte growth factor (HGF)/c-Met signaling have a significantly worse prognosis. c-Met, a high affinity receptor for HGF, plays a critical role in cancer growth, invasion and metastasis. c-Met and CD44 have been utilized as cell surface markers to identify mesenchymal tumor-initiating stem-like cells (TISC) in several cancers including HCC. In this work, we examine the complex relationship between c-Met and CD44s (standar ...[more]