Ontology highlight
ABSTRACT:
SUBMITTER: Ma F
PROVIDER: S-EPMC4380327 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ma Feng F Liu Su-Yang SY Razani Bahram B Arora Neda N Li Bing B Kagechika Hiroyuki H Tontonoz Peter P Núñez Vanessa V Ricote Mercedes M Cheng Genhong G
Nature communications 20141124
The retinoid X receptor α (RXRα), a key nuclear receptor in metabolic processes, is downregulated during host antiviral response. However, the roles of RXRα in host antiviral response are unknown. Here we show that RXRα overexpression or ligand activation increases host susceptibility to viral infections in vitro and in vivo, while Rxra-/- or antagonist treatment reduces infection by the same viruses. Consistent with these functional studies, ligand activation of RXR inhibits the expression of a ...[more]