Ontology highlight
ABSTRACT:
SUBMITTER: Patrick KL
PROVIDER: S-EPMC4380400 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Patrick Kristin L KL Ryan Colm J CJ Xu Jiewei J Lipp Jesse J JJ Nissen Kelly E KE Roguev Assen A Shales Michael M Krogan Nevan J NJ Guthrie Christine C
PLoS genetics 20150331 3
Although numerous regulatory connections between pre-mRNA splicing and chromatin have been demonstrated, the precise mechanisms by which chromatin factors influence spliceosome assembly and/or catalysis remain unclear. To probe the genetic network of pre-mRNA splicing in the fission yeast Schizosaccharomyces pombe, we constructed an epistatic mini-array profile (E-MAP) and discovered many new connections between chromatin and splicing. Notably, the nucleosome remodeler SWI/SNF had strong genetic ...[more]