Ontology highlight
ABSTRACT:
SUBMITTER: Crowley JJ
PROVIDER: S-EPMC4380817 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Crowley James J JJ Zhabotynsky Vasyl V Sun Wei W Huang Shunping S Pakatci Isa Kemal IK Kim Yunjung Y Wang Jeremy R JR Morgan Andrew P AP Calaway John D JD Aylor David L DL Yun Zaining Z Bell Timothy A TA Buus Ryan J RJ Calaway Mark E ME Didion John P JP Gooch Terry J TJ Hansen Stephanie D SD Robinson Nashiya N NN Shaw Ginger D GD Spence Jason S JS Quackenbush Corey R CR Barrick Cordelia J CJ Nonneman Randal J RJ Kim Kyungsu K Xenakis James J Xie Yuying Y Valdar William W Lenarcic Alan B AB Wang Wei W Welsh Catherine E CE Fu Chen-Ping CP Zhang Zhaojun Z Holt James J Guo Zhishan Z Threadgill David W DW Tarantino Lisa M LM Miller Darla R DR Zou Fei F McMillan Leonard L Sullivan Patrick F PF Pardo-Manuel de Villena Fernando F
Nature genetics 20150302 4
Complex human traits are influenced by variation in regulatory DNA through mechanisms that are not fully understood. Because regulatory elements are conserved between humans and mice, a thorough annotation of cis regulatory variants in mice could aid in further characterizing these mechanisms. Here we provide a detailed portrait of mouse gene expression across multiple tissues in a three-way diallel. Greater than 80% of mouse genes have cis regulatory variation. Effects from these variants influ ...[more]