Ontology highlight
ABSTRACT:
SUBMITTER: Yalak G
PROVIDER: S-EPMC4380966 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cancer medicine 20141214 3
While small-molecule kinase inhibitors became the most prominent anticancer drugs, novel combinatorial strategies need to be developed as the fight against cancer is not yet won. We review emerging literature showing that the release of several ectokinases is significantly upregulated in body fluids from cancer patients and that they leave behind their unique signatures on extracellular matrix (ECM) proteins. Our analysis of proteomic data reveals that fibronectin is heavily phosphorylated in ca ...[more]