Ontology highlight
ABSTRACT:
SUBMITTER: Santander AM
PROVIDER: S-EPMC4381255 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Santander Ana M AM Lopez-Ocejo Omar O Casas Olivia O Agostini Thais T Sanchez Lidia L Lamas-Basulto Eduardo E Carrio Roberto R Cleary Margot P MP Gonzalez-Perez Ruben R RR Torroella-Kouri Marta M
Cancers 20150115 1
The relationship between obesity and breast cancer (BC) has focused on serum factors. However, the mammary gland contains adipose tissue (AT) which may enable the crosstalk between adipocytes and tumor cells contributing to tumor macrophage recruitment. We hypothesize that the breast AT (bAT) is inflamed in obese females and plays a major role in breast cancer development. The effects of this interplay on macrophage chemotaxis were examined in vitro, using co-cultures of mouse macrophages, mamma ...[more]