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A recent bottleneck of Y chromosome diversity coincides with a global change in culture.


ABSTRACT: It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

SUBMITTER: Karmin M 

PROVIDER: S-EPMC4381518 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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A recent bottleneck of Y chromosome diversity coincides with a global change in culture.

Karmin Monika M   Saag Lauri L   Vicente Mário M   Wilson Sayres Melissa A MA   Järve Mari M   Talas Ulvi Gerst UG   Rootsi Siiri S   Ilumäe Anne-Mai AM   Mägi Reedik R   Mitt Mario M   Pagani Luca L   Puurand Tarmo T   Faltyskova Zuzana Z   Clemente Florian F   Cardona Alexia A   Metspalu Ene E   Sahakyan Hovhannes H   Yunusbayev Bayazit B   Hudjashov Georgi G   DeGiorgio Michael M   Loogväli Eva-Liis EL   Eichstaedt Christina C   Eelmets Mikk M   Chaubey Gyaneshwer G   Tambets Kristiina K   Litvinov Sergei S   Mormina Maru M   Xue Yali Y   Ayub Qasim Q   Zoraqi Grigor G   Korneliussen Thorfinn Sand TS   Akhatova Farida F   Lachance Joseph J   Tishkoff Sarah S   Momynaliev Kuvat K   Ricaut François-Xavier FX   Kusuma Pradiptajati P   Razafindrazaka Harilanto H   Pierron Denis D   Cox Murray P MP   Sultana Gazi Nurun Nahar GN   Willerslev Rane R   Muller Craig C   Westaway Michael M   Lambert David D   Skaro Vedrana V   Kovačevic Lejla L   Turdikulova Shahlo S   Dalimova Dilbar D   Khusainova Rita R   Trofimova Natalya N   Akhmetova Vita V   Khidiyatova Irina I   Lichman Daria V DV   Isakova Jainagul J   Pocheshkhova Elvira E   Sabitov Zhaxylyk Z   Barashkov Nikolay A NA   Nymadawa Pagbajabyn P   Mihailov Evelin E   Seng Joseph Wee Tien JW   Evseeva Irina I   Migliano Andrea Bamberg AB   Abdullah Syafiq S   Andriadze George G   Primorac Dragan D   Atramentova Lubov L   Utevska Olga O   Yepiskoposyan Levon L   Marjanovic Damir D   Kushniarevich Alena A   Behar Doron M DM   Gilissen Christian C   Vissers Lisenka L   Veltman Joris A JA   Balanovska Elena E   Derenko Miroslava M   Malyarchuk Boris B   Metspalu Andres A   Fedorova Sardana S   Eriksson Anders A   Manica Andrea A   Mendez Fernando L FL   Karafet Tatiana M TM   Veeramah Krishna R KR   Bradman Neil N   Hammer Michael F MF   Osipova Ludmila P LP   Balanovsky Oleg O   Khusnutdinova Elza K EK   Johnsen Knut K   Remm Maido M   Thomas Mark G MG   Tyler-Smith Chris C   Underhill Peter A PA   Willerslev Eske E   Nielsen Rasmus R   Metspalu Mait M   Villems Richard R   Kivisild Toomas T  

Genome research 20150313 4


It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow ti  ...[more]

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