Ontology highlight
ABSTRACT:
SUBMITTER: Gao P
PROVIDER: S-EPMC4381552 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Gao Pu P Zillinger Thomas T Wang Weiyi W Ascano Manuel M Dai Peihong P Hartmann Gunther G Tuschl Thomas T Deng Liang L Barchet Winfried W Patel Dinshaw J DJ
Cell reports 20140904 6
The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials. DMXAA was later discovered to activate mouse, but not human, STING, an adaptor protein in the cyclic dinucleotide cGAMP-mediated signaling pathway, inducing type I interferon expression. To facilitate the development of compounds that target human STING, we combined structural, biophysical, and cellular assays to study mouse and h ...[more]