Ontology highlight
ABSTRACT:
SUBMITTER: Shiraishi T
PROVIDER: S-EPMC4381583 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Shiraishi Takumi T Verdone James E JE Huang Jessie J Kahlert Ulf D UD Hernandez James R JR Torga Gonzalo G Zarif Jelani C JC Epstein Tamir T Gatenby Robert R McCartney Annemarie A Elisseeff Jennifer H JH Mooney Steven M SM An Steven S SS Pienta Kenneth J KJ
Oncotarget 20150101 1
The ability of a cancer cell to detach from the primary tumor and move to distant sites is fundamental to a lethal cancer phenotype. Metabolic transformations are associated with highly motile aggressive cellular phenotypes in tumor progression. Here, we report that cancer cell motility requires increased utilization of the glycolytic pathway. Mesenchymal cancer cells exhibited higher aerobic glycolysis compared to epithelial cancer cells while no significant change was observed in mitochondrial ...[more]