Ontology highlight
ABSTRACT:
SUBMITTER: Lew QJ
PROVIDER: S-EPMC4381594 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Lew Qiao Jing QJ Chu Kai Ling KL Chia Yi Ling YL Soo Benjamin B Ho Jia Pei JP Ng Chew Har CH Kwok Hui Si HS Chiang Cheng-Ming CM Chang Yao Y Chao Sheng-Hao SH
Oncotarget 20150101 1
Cellular unfolded protein response (UPR) is induced when endoplasmic reticulum (ER) is under stress. XBP-1S, the active isoform of X-box binding protein 1 (XBP-1), is a key regulator of UPR. Previously, we showed that a histone acetyltransferase (HAT), p300/CBP-associated factor (PCAF), binds to XBP-1S and functions as an activator of XBP-1S. Here, we identify general control nonderepressible 5 (GCN5), a HAT with 73% identity to PCAF, as a novel XBP-1S regulator. Both PCAF and GCN5 bind to the s ...[more]