MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis.
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ABSTRACT:
SUBMITTER: Ho MY
PROVIDER: S-EPMC4381602 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis.
Ho Ming-Yi MY Liang Chi-Ming CM Liang Shu-Mei SM
Oncotarget 20150101 1
Growth factors and COX-2/PGE2 enhance lung cancer invasion/metastasis via PI3K/Akt and RAS/Raf. Here, we explored their mechanism of action further. We found first that higher levels of migration inducting gene-7 protein (MIG-7) and PHB phosphorylated at threonine 258 (phospho-PHBT258) are positively correlated with advanced stages of human lung cancer in tissue microarray. PGE2 or growth factors such as EGF, HGF and IGF-1 increased complex formation of phospho-PHBT258 with Ras, phospho-AktS473, ...[more]
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